Phosphorylated α-synuclein in Parkinson’s disease: correlation depends on disease severity
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منابع مشابه
Phosphorylated α-synuclein in Parkinson’s disease: correlation depends on disease severity
INTRODUCTION α-Synuclein (α-syn) is a key protein in Parkinson's disease (PD), and one of its phosphorylated forms, pS129, is higher in PD patients than healthy controls. However, few studies have examined its levels in longitudinally collected cerebrospinal fluid (CSF) or in preclinical cases. In this study, CSF and clinical data were contributed by >300 subjects from three cohorts (the longit...
متن کاملYu Wang - Synuclein in Parkinson ' s Disease α Phosphorylated
collected longitudinally. marker for PD, it will need to be validated in independent cohorts of PD patients, especially those with samples available and to monitor disease in response to these treatments. However, before PS-129 can be deployed as a This would be of value for selecting patients for clinical trials to test new PD-modifying therapies as they become PS-129 may be useful as a marker...
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ژورنال
عنوان ژورنال: Acta Neuropathologica Communications
سال: 2015
ISSN: 2051-5960
DOI: 10.1186/s40478-015-0185-3